We gratefully thank the Max Planck Society and the European Research Council (ERC Advanced Grant AUTOHEPARIN to P.H.S.) for financial support. The authors would like to thank Dr. D. Kolarich, Dr. M. Hurevich, Dr. M. Schlegel, and O. Calin for helpful discussions, and Dr. Y.-H. Tsai for measuring the NMR spectra. We also would like to thank Dr. V. Mountain for critically editing this manuscript.
Automated Solid-Phase Synthesis of Chondroitin Sulfate Glycosaminoglycans†
Article first published online: 15 APR 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 22, pages 5858–5861, May 27, 2013
How to Cite
Eller, S., Collot, M., Yin, J., Hahm, H. S. and Seeberger, P. H. (2013), Automated Solid-Phase Synthesis of Chondroitin Sulfate Glycosaminoglycans. Angew. Chem. Int. Ed., 52: 5858–5861. doi: 10.1002/anie.201210132
- Issue published online: 17 MAY 2013
- Article first published online: 15 APR 2013
- Manuscript Received: 19 DEC 2012
- Max Planck Society
- European Research Council
- automated solid-phase synthesis;
- photocleavable linker
Glycosaminoglycans (GAGs) are important sulfated carbohydrates prevalent in the extracellular matrix. The synthesis of structurally defined GAGs requires laborious procedures, and incorporating defined sulfation patterns is challenging. The automated synthesis of defined sulfated chondroitin hexasaccharides on solid support has been achieved using a photolabile linker that is efficiently cleaved in a continuous-flow photoreactor.