Get access

Automated Solid-Phase Synthesis of Chondroitin Sulfate Glycosaminoglycans


  • We gratefully thank the Max Planck Society and the European Research Council (ERC Advanced Grant AUTOHEPARIN to P.H.S.) for financial support. The authors would like to thank Dr. D. Kolarich, Dr. M. Hurevich, Dr. M. Schlegel, and O. Calin for helpful discussions, and Dr. Y.-H. Tsai for measuring the NMR spectra. We also would like to thank Dr. V. Mountain for critically editing this manuscript.


original image

Glycosaminoglycans (GAGs) are important sulfated carbohydrates prevalent in the extracellular matrix. The synthesis of structurally defined GAGs requires laborious procedures, and incorporating defined sulfation patterns is challenging. The automated synthesis of defined sulfated chondroitin hexasaccharides on solid support has been achieved using a photolabile linker that is efficiently cleaved in a continuous-flow photoreactor.

Get access to the full text of this article