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Automated Polysaccharide Synthesis: Assembly of a 30mer Mannoside


  • The Max-Planck Society, the European Research Council (ERC Advanced Grant AUTOHEPARIN to PHS), and the Marie Curie ITN FP7 project CARMUSYS (PITN-GA-2008-213592) are gratefully acknowledged for generous financial support.


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Automated carbohydrate synthesis breaks new grounds: The longest sugar chemically synthesized to date (a 30 mer) has been accessed. Key to the process is the use of a catch–release technique, which labels the saccharide, thus allowing it to be separated later through temporary attachement to magnetic particles.