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Ligand-Accelerated Iron- and Cobalt-Catalyzed Cross-Coupling Reactions between N-Heteroaryl Halides and Aryl Magnesium Reagents

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  • The research leading to these results has received funding from the European Research Council under the European Community’s Seventh Framework Programme (FP7/2007-2013) ERC Grant Agreement No. 227763. We thank the Fonds der Chemischen Industrie for financial support and are grateful to BASF AG, and Rockwood Lithium GmbH for the generous gift of chemicals. O.M.K. thanks the Novartis Pharma AG for financial support.

Abstract

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Quinoline and isoquinoline dramatically increase the rate and yield of Fe- and Co-catalyzed cross-coupling reactions. This new catalytic process extends the scope of such cross-coupling reactions to include complex functional groups and allows heteroaryl–heteroaryl bond formation to occur.

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