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Keywords:

  • alkene;
  • copper;
  • fluorine;
  • heterocycles;
  • homogeneous catalysis
Thumbnail image of graphical abstract

The combo pack: Copper-catalyzed trifluoromethylation of alkenes bearing an allylic proton combined with C[BOND]C bond formation affords the title compounds in good to high yields (see scheme). The reactions are faster than allylic trifluoromethylation, especially in 1,4-dioxane. A unique 1,6-oxytrifluoromethylation occurred instead of an anticipated seven-membered ring forming carbotrifluoromethylation reaction.