The Impact of Palladium(II) Reduction Pathways on the Structure and Activity of Palladium(0) Catalysts


  • We thank Bristol-Myers Squibb, in particular Dr. David Kronenthal and Dr. Robert Waltermire, for support of this work. We also thank the reviewers of this manuscript for many helpful suggestions.


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Two roads diverged: The mechanism of in situ PdII catalyst activation to generate an active {LnPd0} catalyst from an air-stable PdII precursor was examined using the standard conditions of a Miyaura borylation reaction. Two pathways for catalyst activation exist under these conditions, producing two structurally and chemically distinct {LnPd0} complexes (see scheme).