The Impact of Palladium(II) Reduction Pathways on the Structure and Activity of Palladium(0) Catalysts

Authors


  • We thank Bristol-Myers Squibb, in particular Dr. David Kronenthal and Dr. Robert Waltermire, for support of this work. We also thank the reviewers of this manuscript for many helpful suggestions.

Abstract

original image

Two roads diverged: The mechanism of in situ PdII catalyst activation to generate an active {LnPd0} catalyst from an air-stable PdII precursor was examined using the standard conditions of a Miyaura borylation reaction. Two pathways for catalyst activation exist under these conditions, producing two structurally and chemically distinct {LnPd0} complexes (see scheme).

Ancillary