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Keywords:

  • enantioselectivity;
  • heterocycles;
  • ketimines;
  • organocatalysis;
  • synthetic methodology
Thumbnail image of graphical abstract

Key to success: The title reaction provides facile access to enantioenriched 3,4-dihydroquinazolin-2(1H)-ones containing a quaternary stereogenic center in high yields with excellent enantioselectivities. Subsequent transformations lead to the convenient preparation of the anti-HIV drug DPC 083 and N-fused polycyclic compounds without loss of enantiomeric excess.