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Redox-Neutral Copper(II) Carboxylate Catalyzed α-Alkynylation of Amines


  • Financial support from the NIH-NIGMS (R01GM101389-01) is gratefully acknowledged. Partial support (microwave purchase) was provided by the National Science Foundation (Grant CHE-0911192). A.X.S. acknowledges support from the Aresty Research Center for Undergraduates and Rutgers University School of Arts and Sciences. D.S. is a fellow of the Alfred P. Sloan Foundation and the recipient of an Amgen Young Investigator Award.


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Cocktail of three: A new strategy for iminium ion isomerization was applied to the direct, redox-neutral α-alkynylation of amines. Copper(II) 2-ethylhexanoate [Cu(2-EH)2] was identified as the optimal catalyst for this three-component coupling reaction of secondary amines, aldehydes, and alkynes. MW=microwave.

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