These authors contributed equally to this work.
Back Cover: Rewiring Translation for Elongation Factor Tu-Dependent Selenocysteine Incorporation (Angew. Chem. Int. Ed. 5/2013)
Article first published online: 20 JAN 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 5, page 1596, January 28, 2013
How to Cite
Aldag, C., Bröcker, M. J., Hohn, M. J., Prat, L., Hammond, G., Plummer, A. and Söll, D. (2013), Back Cover: Rewiring Translation for Elongation Factor Tu-Dependent Selenocysteine Incorporation (Angew. Chem. Int. Ed. 5/2013). Angew. Chem. Int. Ed., 52: 1596. doi: 10.1002/anie.201300063
- Issue published online: 23 JAN 2013
- Article first published online: 20 JAN 2013
- genetic code;
- orthogonal translation;
- protein engineering;
- synthetic biology
Synthetic tRNA for selenoprotein production is described by D. Söll et al. in their Communication on page 1441 ff. The tRNA is a substrate for three E. coli proteins: seryl-tRNA synthetase (SerRS), selenocysteine synthase (SelA) generating Sec-tRNAUTu, and EF-Tu for Sec-tRNAUTu transport to the ribosome, which allows site-specific Sec insertion into proteins. This system has general utility in protein engineering, molecular biology, and disease research.