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The Catalytic Asymmetric Acetalization


  • We thank H. Schucht for crystal structure analyses. Generous support from the Max Planck Society and the European Research Council (Advanced Grant “High Performance Lewis Acid Organocatalysis, HIPOCAT”) is gratefully acknowledged.


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In straitened circumstances: In an asymmetric version of the acid-catalyzed acetalization of aldehydes, a novel member of the chiral confined Brønsted acid family significantly outperformed previously established catalysts, providing cyclic acetals with excellent enantioselectivity (see scheme; Ar=2-iPr-5-MeC6H3).

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