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The Catalytic Asymmetric Acetalization

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  • We thank H. Schucht for crystal structure analyses. Generous support from the Max Planck Society and the European Research Council (Advanced Grant “High Performance Lewis Acid Organocatalysis, HIPOCAT”) is gratefully acknowledged.

Abstract

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In straitened circumstances: In an asymmetric version of the acid-catalyzed acetalization of aldehydes, a novel member of the chiral confined Brønsted acid family significantly outperformed previously established catalysts, providing cyclic acetals with excellent enantioselectivity (see scheme; Ar=2-iPr-5-MeC6H3).

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