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NIR-Triggered Anticancer Drug Delivery by Upconverting Nanoparticles with Integrated Azobenzene-Modified Mesoporous Silica

Authors

  • Jianan Liu,

    1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai 200050 (China)
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  • Prof. Wenbo Bu,

    Corresponding author
    1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai 200050 (China)
    • State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai 200050 (China)===

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  • Limin Pan,

    1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai 200050 (China)
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  • Prof. Jianlin Shi

    Corresponding author
    1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai 200050 (China)
    • State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai 200050 (China)===

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  • This work was financially supported by the National Natural Science Foundation of China Research (grant numbers 50823007, 50972154, 51132009, 51072212, and 21172043), the Shanghai Rising-Star Program (grant number 12QH1402500), the Nano special program of the Science and Technology Commission of Shanghai (grant number 11nm0505000), the Development Foundation for Talents of Shanghai (grant number2012035), the National Basic Research Program of China (973 Program, grant number 2011CB707905).

Abstract

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Photomediated drug release: Silica-coated upconverting nanoparticles with mesopores modified by azobenzene molecules were synthesized. The azobenzene molecules make possible the release of the anticancer drug doxorubicin from the pore network of the mesoporous silica outer layer by irradiation with near-infrared (NIR) laser light. The release is regulated by the transcis photoisomerization of the azobenzene molecules (see picture).

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