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Keywords:

  • chromatography;
  • DNA separation;
  • electroosmotic pump;
  • integrated system;
  • microfluidic chip
Thumbnail image of graphical abstract

Turn the volume down: Coupling a high-pressure electroosmotic pump (EOP) and a microfabricated chip-injector with a bare narrow capillary–hydrodynamic chromatographic system (BaNC-HDC), enables samples to be injected at low-picoliter volumes, analytes to be eluted at picoliters per minute, and a wide size range of DNA fragments to be resolved (see picture) rapidly in free solution at the single-molecule level.