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Keywords:

  • click chemistry;
  • lysine malonylation;
  • metabolic labeling;
  • posttranslational modifications;
  • protein modifications
Thumbnail image of graphical abstract

Tag! You′re it! MalAM-yne is a chemical reporter for malonylation of lysines within proteins (see scheme), a newly identified posttranslational modification. MalAM-yne is cell-permeable and metabolically incorporated into proteins in living cells. Subsequent bioorthogonal tag conjugation allows the fluorescent visualization of cellular malonylation and profiling of malonylated proteins.