This work was supported by Grants-in-Aid for Scientific Research on Challenging Exploratory Research, MEXT and ACT-C, JST to M.S. and by Grant-in-Aid for Young Scientists (Start-up), JSPS to T.I. H.I. thanks JSPS for support through a scholarship.
Construction of Eight-Membered Carbocycles through Gold Catalysis with Acetylene-Tethered Silyl Enol Ethers†
Article first published online: 4 MAR 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 15, pages 4239–4242, April 8, 2013
How to Cite
Iwai, T., Okochi, H., Ito, H. and Sawamura, M. (2013), Construction of Eight-Membered Carbocycles through Gold Catalysis with Acetylene-Tethered Silyl Enol Ethers . Angew. Chem. Int. Ed., 52: 4239–4242. doi: 10.1002/anie.201300265
- Issue published online: 3 APR 2013
- Article first published online: 4 MAR 2013
- Manuscript Received: 11 JAN 2013
- medium-ring compounds;
Semihollow triethynylphosphanes were synthesized and employed as ligands in the gold-catalyzed 8-exo-dig cyclization of acetylene-tethered silyl enol ethers to obtain eight-membered-ring carbocycles (see scheme). The gold–phosphane catalysts promoted either the annulation toward bicyclic structures or the cyclization of acyclic molecules to form nonfused carbocycles. Tf=Trifluoromethylsulfonyl.