• Open Access

Synthesis of Aldehydic Ribonucleotide and Amino Acid Precursors by Photoredox Chemistry

Authors

  • Dr. Dougal J. Ritson,

    1. MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH (UK)
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  • Prof. Dr. John D. Sutherland

    Corresponding author
    1. MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH (UK)
    • MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH (UK)

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  • This work was funded by the Medical Research Council (project no. MC_UP_A024_1009), the Engineering and Physical Sciences Research Council, and by the Origins of Life Challenge; we thank Harry Lonsdale for the latter. Thanks also to Willie Motherwell for bringing certain key references to our attention.

Abstract

original image

Light work: UV irradiation of a system formed by adding copper(I) cyanide to an aqueous solution of glycolonitrile, sodium phosphate, and hydrogen sulfide efficiently generates aldehyde precursors to the building blocks of RNA and proteins.

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