Inside Back Cover: Discovery of Hepatitis C Virus NS3 Helicase Inhibitors by a Multiplexed, High-Throughput Helicase Activity Assay Based on Graphene Oxide (Angew. Chem. Int. Ed. 8/2013)

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Abstract

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DNA helicases are important targets for anti-viral drug development. In their Communication on page 2340 ff., D.-H. Min et al. use graphene oxide for high-throughput chemical screening to discover new inhibitors of two different helicases derived from hepatitis C virus and severe acute respiratory syndrome (SARS) coronavirus in a multiplexed assay. The developed assay can also be used to validate hits from the helicase inhibitor screen.

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