Breathing Polymersomes: CO2-Tuning Membrane Permeability for Size-Selective Release, Separation, and Reaction


  • This work was financially supported by the National Basic Research Program (2009CB930602) and the National Natural Science Foundation of China (51073090 and 21174076). The authors acknowledge the help of J. X. Ma at the Beijing Chemical Research Centre with PEI compounds and enzyme-loaded experiments.


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Take a deep breath: The membrane permeability and the scale of membrane nanochannels of polymer vesicles are modulated by CO2 control of vesicular expansion and contraction. These polymersomes can act as size-selective nanoseparators for particle sieving and as nanoreactors for enzymatic reactions that require compartmentalization. GSH=glutathione.