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Palladium-Catalyzed Ortho-Selective C[BOND]F Activation of Polyfluoroarenes with Triethylsilane: A Facile Access to Partially Fluorinated Aromatics

Authors

  • Zhao Chen,

    1. School of Chemistry and Chemical Engineering, Southwest Petroleum University, 8 Xindu Avenue, Chendu, Sichuan 610500 (China)
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  • Chun-Yang He,

    1. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 345 Lingling Lu, Shanghai 200032 (China)
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  • Zengsheng Yin,

    1. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 345 Lingling Lu, Shanghai 200032 (China)
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  • Liye Chen,

    1. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 345 Lingling Lu, Shanghai 200032 (China)
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  • Yi He,

    1. School of Chemistry and Chemical Engineering, Southwest Petroleum University, 8 Xindu Avenue, Chendu, Sichuan 610500 (China)
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  • Prof. Dr. Xingang Zhang

    Corresponding author
    1. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 345 Lingling Lu, Shanghai 200032 (China)
    • Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 345 Lingling Lu, Shanghai 200032 (China)

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  • This work was financially supported by the National Basic Research Program of China (973 Program) (No. 2012CB821600), the NSFC (No 21172242), and SIOC.

Abstract

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PdF: A simple catalytic system, broad substrate scope, and high versatility provide a useful and facile access to partially fluorinated aromatics (see scheme). Tuning the reaction conditions enables a diverse range of product structures to be prepared.

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