Inside Cover: Two-Way Nanopore Sensing of Sequence-Specific Oligonucleotides and Small-Molecule Targets in Complex Matrices Using Integrated DNA Supersandwich Structures (Angew. Chem. Int. Ed. 7/2013)

Authors

  • Nannan Liu,

    1. School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074 (P.R. China)
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    • These authors contributed equally to this work.

  • Yanan Jiang,

    1. School of Chemistry and Environment, Beijing University of Aeronautics and Astronautics, Beijing 100191 (P.R. China)
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    • These authors contributed equally to this work.

  • Yahong Zhou,

    1. Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China)
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  • Prof. Fan Xia,

    Corresponding author
    1. School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074 (P.R. China)
    • School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074 (P.R. China)
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  • Dr. Wei Guo,

    Corresponding author
    1. Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China)
    • Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China)
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  • Prof. Lei Jiang

    1. Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China)
    2. School of Chemistry and Environment, Beijing University of Aeronautics and Astronautics, Beijing 100191 (P.R. China)
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Abstract

original image

DNA supersandwich structures work as gatekeepers for solid-state nanopores as part of a target-specific nanofluidic sensor for both oligonucleotides and small molecules, as shown by F. Xia, W. Guo et al. in their Communication on page 2007 ff. The DNA superstructures enhance the sensitivity and reduce the background signal, so that the biohybrid nanodevice also works well in complex mixtures, such as mammalian serum.

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