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Keywords:

  • cancer therapy;
  • controlled release;
  • polymer–drug conjugate;
  • polymers;
  • trigger-responsive polymer
Thumbnail image of graphical abstract

Trigger happy: Trigger-responsive chain-shattering polymeric therapeutics (CSPTs) were prepared by condensation polymerization of a UV- or hydrogen peroxide-responsive domain and a drug as co-monomers. Drug release can be started and stopped by starting and stopping the trigger treatment. Chemotherapeutic-containing CSPTs showed trigger-responsive in vitro and in vivo antitumor efficacy.