Chain-Shattering Polymeric Therapeutics with On-Demand Drug-Release Capability

Authors

  • Yanfeng Zhang,

    1. Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 West Green Street, Urbana, IL, 61801 (USA)
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  • Qian Yin,

    1. Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 West Green Street, Urbana, IL, 61801 (USA)
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  • Lichen Yin,

    1. Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 West Green Street, Urbana, IL, 61801 (USA)
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  • Liang Ma,

    1. Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 West Green Street, Urbana, IL, 61801 (USA)
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  • Li Tang,

    1. Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 West Green Street, Urbana, IL, 61801 (USA)
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  • Prof. Dr. Jianjun Cheng

    Corresponding author
    1. Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 West Green Street, Urbana, IL, 61801 (USA)
    • Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 West Green Street, Urbana, IL, 61801 (USA)

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  • This work is supported by Dow Chemical Company. We thank Dr. Liang Hong and Dr. Keith Harris for helpful discussion. Q.Y. was funded at UIUC from NIH National Cancer Institute Alliance for Nanotechnology in Cancer “Midwest Cancer Nanotechnology Training Center” Grant R25 CA154015A.

Abstract

original image

Trigger happy: Trigger-responsive chain-shattering polymeric therapeutics (CSPTs) were prepared by condensation polymerization of a UV- or hydrogen peroxide-responsive domain and a drug as co-monomers. Drug release can be started and stopped by starting and stopping the trigger treatment. Chemotherapeutic-containing CSPTs showed trigger-responsive in vitro and in vivo antitumor efficacy.

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