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A Palladium/Chiral Amine Co-catalyzed Enantioselective Dynamic Cascade Reaction: Synthesis of Polysubstituted Carbocycles with a Quaternary Carbon Stereocenter

Authors

  • Dr. Guangning Ma,

    1. Department of Natural Sciences, Engineering and Mathematics, Mid Sweden University, 85170 Sundsvall (Sweden)
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  • Samson Afewerki,

    1. Department of Natural Sciences, Engineering and Mathematics, Mid Sweden University, 85170 Sundsvall (Sweden)
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  • Luca Deiana,

    1. Department of Organic Chemistry, The Arrhenius Laboratory, Stockholm University (Sweden)
    2. The Berzelii Center EXSELENT, Stockholm University (Sweden)
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  • Carlos Palo-Nieto,

    1. Department of Organic Chemistry, The Arrhenius Laboratory, Stockholm University (Sweden)
    2. The Berzelii Center EXSELENT, Stockholm University (Sweden)
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  • Leifeng Liu,

    1. The Berzelii Center EXSELENT, Stockholm University (Sweden)
    2. Department of Materials and Environmental Chemistry, Stockholm University (Sweden)
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  • Junliang Sun,

    1. The Berzelii Center EXSELENT, Stockholm University (Sweden)
    2. Department of Materials and Environmental Chemistry, Stockholm University (Sweden)
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  • Prof. Dr. Ismail Ibrahem,

    Corresponding author
    1. Department of Natural Sciences, Engineering and Mathematics, Mid Sweden University, 85170 Sundsvall (Sweden)
    • Department of Natural Sciences, Engineering and Mathematics, Mid Sweden University, 85170 Sundsvall (Sweden)

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  • Prof. Dr. Armando Córdova

    Corresponding author
    1. Department of Natural Sciences, Engineering and Mathematics, Mid Sweden University, 85170 Sundsvall (Sweden)
    2. Department of Organic Chemistry, The Arrhenius Laboratory, Stockholm University (Sweden)
    3. The Berzelii Center EXSELENT, Stockholm University (Sweden)
    • Department of Natural Sciences, Engineering and Mathematics, Mid Sweden University, 85170 Sundsvall (Sweden)

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Abstract

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Polysubstituted 5- and 6-membered carbocycles were synthesized by the title reaction. The one-pot dynamic relay process generates four new stereocenters, including a quaternary carbon center, in a highly enantioselective fashion (99.5:0.5→99:0.5 e.r.) by using a simple combination of palladium and chiral amine co-catalysts.

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