Get access
Advertisement

Intramolecular Larock Indole Synthesis: Preparation of 3,4-Fused Tricyclic Indoles and Total Synthesis of Fargesine

Authors

  • Dong Shan,

    1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191 (China)
    Search for more papers by this author
  • Yan Gao,

    1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191 (China)
    Search for more papers by this author
  • Prof. Yanxing Jia

    Corresponding author
    1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191 (China)
    2. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000 (China)
    • State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191 (China)
    Search for more papers by this author

  • We are grateful to the National Natural Science Foundation of China (Nos. 21290180, 20972007), the National Basic Research Program of China (973 Program, NO. 2010CB833200), and the Ph.D. Programs Foundation of the Ministry of Education of China (No. 20120001110100) for their financial support.

Abstract

original image

Core strength: A new and general strategy for the construction of 3,4-fused tricyclic indoles, which are the core structure of numerous natural products and bioactive molecules, has been developed. The method involves a one-step intramolecular Larock indolization and was successfully applied to the first total synthesis of fargesine.

Get access to the full text of this article

Ancillary