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Direct Synthesis of Pyrroles by Dehydrogenative Coupling of β-Aminoalcohols with Secondary Alcohols Catalyzed by Ruthenium Pincer Complexes


  • This research was supported by the European Research Council under the FP7 framework (ERC No 246837) and by the MINERVA Foundation. D. M. holds the Israel Matz Professorial Chair of Organic Chemistry.


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Pyrroles were synthesized in one step by using the acceptorless dehydrogenative coupling of amino alcohols with secondary alcohols (equivalent amounts), catalyzed by ruthenium pincer complexes (0.5 mol %) and a base (less than stoichiometric amounts) through selective C[BOND]N and C[BOND]C bond formation. This atom-economical, environmentally friendly methodology offers easy access to a range of substituted pyrroles in moderate to good yields.

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