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Keywords:

  • alkynes;
  • annulation;
  • diaryliodonium;
  • nitriles;
  • nitrogen heterocycles
Thumbnail image of graphical abstract

Three become one: Multiply substituted quinolines were synthesized from diaryliodoniums, alkynes, and nitriles by a CuII-catalyzed method. This cascade annulation is highly regioselective, step-economic, flexible with regard to the functional groups, and could potentially be applied to the synthesis of complex molecules.