Get access
Advertisement

Copper(II)-Catalyzed Three-Component Cascade Annulation of Diaryliodoniums, Nitriles, and Alkynes: A Regioselective Synthesis of Multiply Substituted Quinolines

Authors

  • Yong Wang,

    1. Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084 (China)
    2. College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042 (China)
    Search for more papers by this author
  • Prof. Dr. Chao Chen,

    Corresponding author
    1. Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084 (China)
    • Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084 (China)
    Search for more papers by this author
  • Jing Peng,

    1. Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084 (China)
    Search for more papers by this author
  • Prof. Dr. Ming Li

    1. College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042 (China)
    Search for more papers by this author

  • This work was supported by National Natural Science Foundation of China (21102080) and Tsinghua University Initiative Scientific Research Program (2011Z02150).

Abstract

original image

Three become one: Multiply substituted quinolines were synthesized from diaryliodoniums, alkynes, and nitriles by a CuII-catalyzed method. This cascade annulation is highly regioselective, step-economic, flexible with regard to the functional groups, and could potentially be applied to the synthesis of complex molecules.

Get access to the full text of this article

Ancillary