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Keywords:

  • allylic substitution;
  • asymmetric catalysis;
  • carbene ligands;
  • copper;
  • silicon
Thumbnail image of graphical abstract

Gamma way: Regio- and enantioselective allylic substitution with a silicon nucleophile generated by copper(I)-catalyzed Si[BOND]B bond activation provides direct access to α-chiral allylic silanes from linear acceptors. The enantioconvergent catalysis employing McQuade's six-membered N-heterocyclic-carbene–copper(I) catalyst is applicable to aryl- and alkyl-substituted allylic phosphates (see scheme).