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Keywords:

  • drug delivery;
  • γ radiation;
  • peptide amphiphiles;
  • responsive gels;
  • selenium-containing polymers
Thumbnail image of graphical abstract

An overwhelming response: The exposure of a supramolecular hydrogel based on a diselenide-containing polymer and a peptide amphiphile containing a drug moiety to γ radiation led to a gel–sol transition owing to the oxidative cleavage of diselenide bonds in the polymer main chain (see picture). The hydrogel can also act as a UV-mediated drug self-delivery system and suggests a new avenue for combined radio- and chemotherapy.