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γ-Ray-Responsive Supramolecular Hydrogel Based on a Diselenide-Containing Polymer and a Peptide

Authors

  • Wei Cao,

    1. Key Laboratory of Organic Optoelectronics and Molecular, Engineering, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
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  • Xiaoli Zhang,

    1. State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071 (China)
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  • Xiaoming Miao,

    1. State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071 (China)
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  • Prof. Zhimou Yang,

    Corresponding author
    1. State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071 (China)
    • Zhimou Yang, State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071 (China)

      Huaping Xu, Key Laboratory of Organic Optoelectronics and Molecular, Engineering, Department of Chemistry, Tsinghua University, Beijing 100084 (China)

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  • Prof. Huaping Xu

    Corresponding author
    1. Key Laboratory of Organic Optoelectronics and Molecular, Engineering, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
    • Zhimou Yang, State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071 (China)

      Huaping Xu, Key Laboratory of Organic Optoelectronics and Molecular, Engineering, Department of Chemistry, Tsinghua University, Beijing 100084 (China)

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  • This research was supported financially by the National Basic Research Program of China (2013CB834502), the National Natural Science Foundation of China (21074066, 51222303), the Foundation for Innovative Research Groups of the National Natural Science Foundation of China (21121004), Tsinghua University Initiative Scientific Research Program (2012Z02131), and an NSFC-DFG joint grant (TRR 61). We acknowledge Prof. Xi Zhang (Tsinghua University) for his stimulating suggestions and discussions, and Prof. Zhibo Li (Institute of Chemistry, Chinese Academy of Sciences) for cryo-TEM measurements.

Abstract

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An overwhelming response: The exposure of a supramolecular hydrogel based on a diselenide-containing polymer and a peptide amphiphile containing a drug moiety to γ radiation led to a gel–sol transition owing to the oxidative cleavage of diselenide bonds in the polymer main chain (see picture). The hydrogel can also act as a UV-mediated drug self-delivery system and suggests a new avenue for combined radio- and chemotherapy.

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