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Construction of Protein Nanowires through Cucurbit[8]uril-based Highly Specific Host–Guest Interactions: An Approach to the Assembly of Functional Proteins

Authors

  • Dr. Chunxi Hou,

    1. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Road, Changchun 130012 (China)
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  • Jiaxi Li,

    1. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Road, Changchun 130012 (China)
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  • Linlu Zhao,

    1. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Road, Changchun 130012 (China)
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  • Dr. Wei Zhang,

    1. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Road, Changchun 130012 (China)
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  • Dr. Quan Luo,

    1. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Road, Changchun 130012 (China)
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  • Dr. Zeyuan Dong,

    1. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Road, Changchun 130012 (China)
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  • Jiayun Xu,

    1. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Road, Changchun 130012 (China)
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  • Prof. Dr. Junqiu Liu

    Corresponding author
    1. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Road, Changchun 130012 (China)
    • State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Road, Changchun 130012 (China)

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  • We acknowledge financial support from the Natural Science Foundation of China (21234004, 91027023, 21221063, 21004028) and the 111 project (B06009).

Abstract

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Getting your proteins in a row: Self-assembled protein nanowires were designed by utilizing highly specific supramolecular interactions of cucurbit[8]uril (CB[8]) and a tripeptide FGG-tag attached on the N-termini of dimeric glutathione S-transferase (GST). With the aid of enzyme simulation, model protein GST was converted into a selenoenzyme glutathione peroxidase mimic, and the CB[8]-induced Se-FGG-GST(Y6C) nanowires demonstrated excellent antioxidative capacity.

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