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Keywords:

  • asymmetric synthesis;
  • biocatalysis;
  • enzyme cascades;
  • phenylpropanolamine;
  • ω-transaminase
Thumbnail image of graphical abstract

Two steps in one pot: An enzyme cascade consisting of a lyase and an (R)- or (S)-selective ω-transaminase (TA) provides (1R,2R)-norpseudoephedrine and (1R,2S)-norephedrine in only two steps. The intermediate is not isolated in this one-pot reaction and the products are obtained in high enantio- and diastereomeric purity. Moreover, the by-product from the second reaction can be recycled to serve as the substrate for the first reaction.