This work was supported by the CLIB Graduate Cluster Industrial Biotechnology of the Heinrich-Heine-University Düsseldorf and financed by the DFG (German Research Foundation) in the frame of Research Group FOR 1296.
Two Steps in One Pot: Enzyme Cascade for the Synthesis of Nor(pseudo)ephedrine from Inexpensive Starting Materials†
Article first published online: 9 MAY 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 26, pages 6772–6775, June 24, 2013
How to Cite
Sehl, T., Hailes, H. C., Ward, J. M., Wardenga, R., von Lieres, E., Offermann, H., Westphal, R., Pohl, M. and Rother, D. (2013), Two Steps in One Pot: Enzyme Cascade for the Synthesis of Nor(pseudo)ephedrine from Inexpensive Starting Materials . Angew. Chem. Int. Ed., 52: 6772–6775. doi: 10.1002/anie.201300718
- Issue published online: 20 JUN 2013
- Article first published online: 9 MAY 2013
- Manuscript Received: 27 JAN 2013
- Heinrich-Heine-University Düsseldorf
- DFG (German Research Foundation)
- asymmetric synthesis;
- enzyme cascades;
Two steps in one pot: An enzyme cascade consisting of a lyase and an (R)- or (S)-selective ω-transaminase (TA) provides (1R,2R)-norpseudoephedrine and (1R,2S)-norephedrine in only two steps. The intermediate is not isolated in this one-pot reaction and the products are obtained in high enantio- and diastereomeric purity. Moreover, the by-product from the second reaction can be recycled to serve as the substrate for the first reaction.