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Keywords:

  • anti-inflammatory agents;
  • C[BOND]H insertion;
  • isoprostanoids;
  • natural products;
  • oxidized phospholipids
Thumbnail image of graphical abstract

Anti-inflammatory: The efficient and general synthetic route to the elusive epoxyisoprostanoid phospholipids PECPC and PEIPC, along with the isoprostanoids EC and EI, relies on a number of stereo- and chemoselective steps, including a C[BOND]H insertion for the rapid construction of the cyclopentanone ring. The synthesized compounds display unprecedented biological activity in reducing the secretion of pro-inflammatory cytokines.