Identification of Cystathionine β-Synthase Inhibitors Using a Hydrogen Sulfide Selective Probe

Authors


  • This work was supported by the American Heart Association (award 11GRNT7530023 to A.M.B.).

Abstract

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Buzzing with activity: A hydrogen sulfide selective fluorogenic probe, 7-azido-4-methylcoumarin (AzMC), serves as a highly sensitive assay for cystathionine β-synthase activity, and is suitable for the high-throughput discovery of novel enzyme inhibitors.

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