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Keywords:

  • directing group;
  • Pauson–Khand reaction;
  • regioselectivity;
  • synthetic methods;
  • trifluoromethyl alkynes
Thumbnail image of graphical abstract

Against the rules: The synthesis of the previously unknown β-substituted regioisomers of the intermolecular Pauson–Khand reaction of terminal alkynes is reported. This regiochemistry was achieved by using the trifluoromethyl group as a removable directing group on the alkyne.