Financial support was partially provided by MEXT, KAKENHI (21200033, 24105512), the Program for Leading Graduate Schools: IGER Program in Green Natural Sciences (MEXT), and the Yazaki Memorial Foundation for Science and Technology. T.H. is grateful for a JSPS Research Fellowship for Young Scientists.
Chiral Magnesium(II) Binaphtholates as Cooperative Brønsted/Lewis Acid–Base Catalysts for the Highly Enantioselective Addition of Phosphorus Nucleophiles to α,β-Unsaturated Esters and Ketones†
Article first published online: 13 MAR 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 17, pages 4549–4553, April 22, 2013
How to Cite
Hatano, M., Horibe, T. and Ishihara, K. (2013), Chiral Magnesium(II) Binaphtholates as Cooperative Brønsted/Lewis Acid–Base Catalysts for the Highly Enantioselective Addition of Phosphorus Nucleophiles to α,β-Unsaturated Esters and Ketones. Angew. Chem. Int. Ed., 52: 4549–4553. doi: 10.1002/anie.201300938
- Issue published online: 18 APR 2013
- Article first published online: 13 MAR 2013
- Manuscript Received: 2 FEB 2013
- KAKENHI. Grant Numbers: 21200033, 24105512
- acid–base catalysts;
- P ligands
A little cooperation goes a long way: The cooperative Brønsted/Lewis acid–base supramolecular catalysts formed in situ from simple chiral magnesium(II) binaphtholate aqua complexes promoted the highly enantioselective 1,4-hydrophosphinylation of α,β-unsaturated esters with diaryl phosphine oxides and 1,2-hydrophosphonylation of α,β-unsaturated ketones with dialkyl phosphites (see scheme).