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PdCl2 and N-Hydroxyphthalimide Co-catalyzed Cmath formula[BOND]H Hydroxylation by Dioxygen Activation


  • Financial support from the National Basic Research Program of China (973 Program 2009CB825300), the National Science Foundation of China (No. 21172006), and Peking University are greatly appreciated. We thank Hang Yin in this group for reproducing the results for 2 j and 2 s.


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Rad transition: The combination of transition-metal-catalyzed C[BOND]H activation and a NHPI-initiated radical process is essential for the title transformation. The neutral conditions and the ideal oxidant, molecular oxygen, make this hydroxylation environmentally friendly and practical. NHPI=N-hydroxyphthalimide.