This research was supported by the European Research Council under the FP7 framework, (ERC No 246837) and by the Kimmel Center for Molecular design. J.R.K. is a recipient of a Dean of Faculty Fellowship. D.M. is the holder of the Israel Matz Professorial Chair of Organic Chemistry.
Direct Deamination of Primary Amines by Water To Produce Alcohols†
Article first published online: 25 APR 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 24, pages 6269–6272, June 10, 2013
How to Cite
Khusnutdinova, J. R., Ben-David, Y. and Milstein, D. (2013), Direct Deamination of Primary Amines by Water To Produce Alcohols. Angew. Chem. Int. Ed., 52: 6269–6272. doi: 10.1002/anie.201301000
- Issue published online: 5 JUN 2013
- Article first published online: 25 APR 2013
- Manuscript Revised: 6 MAR 2013
- Manuscript Received: 4 FEB 2013
- European Research Council. Grant Number: ERC No 246837
- pincer ligands;
Just add water! The title reaction is catalyzed by an acridine-based pincer complex (1, see scheme). This one-step transformation uses water as the only reagent in the absence of additional bases, oxidants, or reductants. Cyclization of 1,4-diaminobutane and 1,6-diaminohexane catalyzed by 1 leads to the formation of pyrrolidine and azepane, respectively.