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Keywords:

  • aldol reaction;
  • organocatalysis;
  • spirocompounds;
  • synthetic methods;
  • vinylogous reactivity
Thumbnail image of graphical abstract

Remote control: The title reaction facilitates the synthesis of complex chiral molecules while selectively forging multiple stereocenters at distant positions, namely five and six bond lengths away from the catalyst chiral fragment (see scheme; Boc=tert-butoxycarbonyl). The potential of the strategy is demonstrated through the one-step preparation of spirocyclopentane oxindoles having four contiguous stereocenters.