Enzyme Promiscuity: Using a P450 Enzyme as a Carbene Transfer Catalyst

Authors


Abstract

original image

How about this for a change: The promiscuous enzyme cytochrome P450-BM3 catalyzes the cyclopropanation of olefins, sometimes with high stereoselectivity (see scheme). The highlighted paper demonstrates that it is possible to design unusual enzyme promiscuity.

Ancillary