Unveiling Latent α-Iminocarbene Reactivity for Intermolecular Cascade Reactions through Alkyne Oxidative Amination


  • We are grateful for financial support from the NSF (CHE 0847258).


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Setting a trap: Described is the development of a metallonitrene-initiated alkyne oxidation cascade with intermolecular trapping of the reactive intermediate with a variety of allyl ethers to provide α-oxyimine products in which new C[DOUBLE BOND]N, C[BOND]O, and C[BOND]C bonds have all been generated (see Scheme; tfacam=trifluoroacetamide).