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Keywords:

  • asymmetric catalysis;
  • enantioselectivity;
  • hydrogen transfer;
  • isoquinolines;
  • ruthenium
Thumbnail image of graphical abstract

Give me an H! Give me another H! The first general and highly enantioselective Ru-catalyzed transfer hydrogenation of a wide range of 1-aryl-substituted 1,2,3,4-dihydroisoquinolines is described. This atom-economic reaction proceeds under mild conditions, allowing rapid access to the corresponding biologically relevant 1-aryl-tetrahydroisoquinoline derivatives, in high yields and enantioselectivities of up to 99 %.