Z.W. and M.P. are grateful to the Ministère de l’Education Nationale et de la Recherche for financial support (2010–2013).
Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of 1-Aryl-Substituted Dihydroisoquinolines: Access to Valuable Chiral 1-Aryl-Tetrahydroisoquinoline Scaffolds†
Article first published online: 26 MAR 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 18, pages 4925–4928, April 26, 2013
How to Cite
Wu, Z., Perez, M., Scalone, M., Ayad, T. and Ratovelomanana-Vidal, V. (2013), Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of 1-Aryl-Substituted Dihydroisoquinolines: Access to Valuable Chiral 1-Aryl-Tetrahydroisoquinoline Scaffolds . Angew. Chem. Int. Ed., 52: 4925–4928. doi: 10.1002/anie.201301134
- Issue published online: 21 APR 2013
- Article first published online: 26 MAR 2013
- Manuscript Received: 7 FEB 2013
- Ministère de l’Education Nationale et de la Recherche
- asymmetric catalysis;
- hydrogen transfer;
Give me an H! Give me another H! The first general and highly enantioselective Ru-catalyzed transfer hydrogenation of a wide range of 1-aryl-substituted 1,2,3,4-dihydroisoquinolines is described. This atom-economic reaction proceeds under mild conditions, allowing rapid access to the corresponding biologically relevant 1-aryl-tetrahydroisoquinoline derivatives, in high yields and enantioselectivities of up to 99 %.