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Multi-Chromatic pH-Activatable 19F-MRI Nanoprobes with Binary ON/OFF pH Transitions and Chemical-Shift Barcodes

Authors

  • Dr. Xiaonan Huang,

    1. Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
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  • Dr. Gang Huang,

    1. Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
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  • Dr. Shanrong Zhang,

    1. Advance Imaging Research Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
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  • Dr. Koji Sagiyama,

    1. Advance Imaging Research Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
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  • Dr. Osamu Togao,

    1. Advance Imaging Research Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
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  • Dr. Xinpeng Ma,

    1. Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
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  • Dr. Yiguang Wang,

    1. Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
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  • Yang Li,

    1. Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
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  • Dr. Todd C. Soesbe,

    1. Advance Imaging Research Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
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  • Dr. Baran D. Sumer,

    1. Department of Otolaryngology, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
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  • Prof. Masaya Takahashi,

    1. Advance Imaging Research Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
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  • Prof. A. Dean Sherry,

    1. Advance Imaging Research Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
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  • Prof. Jinming Gao

    Corresponding author
    1. Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
    • Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
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  • This work is supported by the NIH (R01CA129011, R01EB013149). We acknowledge the assistance of the Southwestern Small Animal Imaging Resource, which is supported in part by NCI U24 CA126608, the Simmons Cancer Center through an NCI Cancer Center Support Grant (P30 CA142543).

Abstract

original image

Imaging all the people: Using ionizable diblock copolymers a series of nanoprobes encoded with different 19F reporters for specific pH transitions is prepared for use in MRI. The pH response of the nanoprobes is extremely sharp (ΔpHON/OFF≈0.25 pH), and results from the disassembly of polymer micelles (see scheme). A collection of three nanoprobes provides the proof of concept and allows for a qualitative measurement of environmental pH values.

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