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A Short Enantioselective Total Synthesis of (−)-Englerin A


  • We thank Dipl.-Chem. Anne Jäger for X-ray diffraction analysis of epoxide 15.


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Selective oxidations of dienone 2 as well as a ring-closing metathesis to give the hydroazulene framework enabled the 12-step preparation of title compound 1 from (−)-photocitral A (3), which is in turn rapidly available from (−)-isopulegol through dual catalysis.

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