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Keywords:

  • cell-penetrating peptides;
  • cellular uptake;
  • collagen;
  • peptides;
  • protein transduction
Thumbnail image of graphical abstract

Arginine-rich heterotrimeric collagen-like peptides were prepared, and their cellular uptake efficiency was evaluated. The spatial arrangement of the Arg residues (blue in picture) on the triple-helix surface significantly affected the efficacy of the cellular uptake. The collagen-like triple-helical conformation provides these cell-penetrating peptides with a high resistance to proteases. O=L-4-hydroxyproline.