This work was supported in part by a Grant-in-Aid for Challenging Exploratory Research (No. 22659112) from the Japan Society for the Promotion of Science and a Waseda University Grant for Special Research Projects (2008A-047).
Collagen-like Cell-Penetrating Peptides†
Article first published online: 16 APR 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 21, pages 5497–5500, May 17, 2013
How to Cite
Yamazaki, C. M., Nakase, I., Endo, H., Kishimoto, S., Mashiyama, Y., Masuda, R., Futaki, S. and Koide, T. (2013), Collagen-like Cell-Penetrating Peptides . Angew. Chem. Int. Ed., 52: 5497–5500. doi: 10.1002/anie.201301266
- Issue published online: 10 MAY 2013
- Article first published online: 16 APR 2013
- Manuscript Received: 13 FEB 2013
- Japan Society for the Promotion of Science
- cell-penetrating peptides;
- cellular uptake;
- protein transduction
Arginine-rich heterotrimeric collagen-like peptides were prepared, and their cellular uptake efficiency was evaluated. The spatial arrangement of the Arg residues (blue in picture) on the triple-helix surface significantly affected the efficacy of the cellular uptake. The collagen-like triple-helical conformation provides these cell-penetrating peptides with a high resistance to proteases. O=L-4-hydroxyproline.