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Collagen-like Cell-Penetrating Peptides

Authors

  • Dr. Chisato M. Yamazaki,

    1. Department of Chemistry and Biochemistry, School of Advanced Science and Engineering, Waseda University, Shinjuku, Tokyo 169-8555 (Japan)
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  • Dr. Ikuhiko Nakase,

    1. Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011 (Japan)
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  • Hiroyuki Endo,

    1. Department of Chemistry and Biochemistry, School of Advanced Science and Engineering, Waseda University, Shinjuku, Tokyo 169-8555 (Japan)
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  • Saya Kishimoto,

    1. Department of Chemistry and Biochemistry, School of Advanced Science and Engineering, Waseda University, Shinjuku, Tokyo 169-8555 (Japan)
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  • Yoshihiro Mashiyama,

    1. Department of Chemistry and Biochemistry, School of Advanced Science and Engineering, Waseda University, Shinjuku, Tokyo 169-8555 (Japan)
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  • Dr. Ryo Masuda,

    1. Department of Chemistry and Biochemistry, School of Advanced Science and Engineering, Waseda University, Shinjuku, Tokyo 169-8555 (Japan)
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  • Prof. Shiroh Futaki,

    1. Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011 (Japan)
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  • Prof. Takaki Koide

    Corresponding author
    1. Department of Chemistry and Biochemistry, School of Advanced Science and Engineering, Waseda University, Shinjuku, Tokyo 169-8555 (Japan)
    • Department of Chemistry and Biochemistry, School of Advanced Science and Engineering, Waseda University, Shinjuku, Tokyo 169-8555 (Japan)

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  • This work was supported in part by a Grant-in-Aid for Challenging Exploratory Research (No. 22659112) from the Japan Society for the Promotion of Science and a Waseda University Grant for Special Research Projects (2008A-047).

Abstract

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Arginine-rich heterotrimeric collagen-like peptides were prepared, and their cellular uptake efficiency was evaluated. The spatial arrangement of the Arg residues (blue in picture) on the triple-helix surface significantly affected the efficacy of the cellular uptake. The collagen-like triple-helical conformation provides these cell-penetrating peptides with a high resistance to proteases. O=L-4-hydroxyproline.

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