Combination of i-Motif and G-Quadruplex Structures within the Same Strand: Formation and Application


  • J.Z. is the recipient of a Marie Curie International Incoming Fellowship, and this research was supported by grants from the ANR (G4Toolbox, F-DNA, and Oligoswitch) and the Conseil Régional d’Aquitaine (“Chaire d’accueil” to J.L.M.)


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Peaceful coexistence: A double quadruplex composed of an i-motif and a G-quadruplex was constructed within one oligonucleotide strand (see picture). The defined double-quadruplex structure can serve as a NOTIF logic gate on the basis of the fluorescence of crystal violet.