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The Electrophilic α-Amination of α-Alkyl-β-Ketoesters with In Situ Generated Nitrosoformates


  • Financial support by the Fonds der Chemischen Industrie (Germany) (Liebig scholarship) is gratefully acknowledged.


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Lewis acid and oxidation catalysis are merged in the reaction discussed here, which provides access to diversely substituted N-hydroxycarbamates (see scheme). This reaction highlights the potential of nitrosoformates as electrophilic amination reagents as well as the benefits of aerobic oxidation for the formation of highly reactive species.

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