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Keywords:

  • aza-benzoin reaction;
  • enals;
  • N-heterocyclic carbenes;
  • organocatalysis;
  • synthetic methods
Thumbnail image of graphical abstract

α-Amino ketones, which are versatile building blocks for organic synthesis, were obtained with the title reaction. A free hydroxy group on the NHC catalyst was found to be crucial for the reaction, and the possible competing reaction through a homoenolate or enolate was not observed with this catalyst (see scheme).