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Iridium-Catalyzed Enantioselective Hydrogenation of Unsaturated Heterocyclic Acids


  • We thank the National Natural Science Foundation of China, the National Basic Research Program of China (973 Program, No. 2011CB808600), and the Ministry of Education of China (B06005) for financial support.


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Spiral binding: A highly enantioselective hydrogenation of unsaturated heterocyclic acids has been developed by using chiral iridium/spirophosphino oxazoline catalysts (see scheme; BArF=tetrakis[3,5-bis(trifluoromethyl)phenyl]borate, Boc=tert-butoxycarbonyl). This reaction provided an efficient method for the preparation of optically active heterocyclic acids with excellent enantioselectivities.